Senior Scientist - ADC Biology
Pfizer Inc.
Washington – Bothell, NY
Job posting number: #7292301 (Ref:pf-4923261)
Posted: November 3, 2024
Job Description
Senior Scientist (Ph.D.), ADC Biology
Why Patients Need You
At Pfizer we deliver breakthroughs that change patients' lives. The ADC Biology team plays a vital role in this mission through discovering and advancing novel ADCs while utilizing comprehensive biological evaluation of tumor associated antigens and linker payloads. To discover the next generation of therapeutics, we are seeking a highly collaborative scientific leader with expertise in cancer cell biology.
POSITION SUMMARY
The successful candidate will be responsible for designing and executing preclinical discovery research activities in collaboration with cross functional project teams for drug development candidates. This individual will directly contribute to Pfizer Oncology pipeline and will be expected to drive collaborative efforts with cancer biologists, immunologists, chemists, and protein engineers to innovate and develop first-in-class oncology therapies. The successful candidate should have a record of being a strong scientist, team player, strategic thinker, and an effective communicator.
KEY RESPONSIBILITIES
Design, conduct, analyze, interpret and document experiments utilizing a diverse array of techniques aimed at identifying and characterizing novel tumor associated antigens and evaluating novel ADC payloads
Execute molecular and cell-based methodologies including cytotoxicity assays, reporter assays, ELISA, western blotting, WES, in vitro PD assays, and flow cytometry
Leverage cell surface target biology to guide therapeutic design and identify the appropriate preclinical models for therapeutic design validation
Design and execute comprehensive experimental plans that inform and enable project progression. Define clear go/no go criteria for projects in alignment with overall research and corporate strategy
Serve as a subject matter expert in cancer biology; stay abreast of relevant literature and act as an expert resource within research
Work independently and demonstrate the ability to collaboratively contribute to projects outside their own expertise
Present research results and methodologies at meetings with immediate supervisor and/or project leader, project team meetings and other research forums.
Contribute to building a culture that embraces scientific excellence, urgency, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development
QUALIFICATIONS
Ph.D. degree or equivalent experience in Cancer Biology, Cell biology, Biochemistry, Engineering or a related field
Post-doctoral training in Cancer Biology or a related field is strongly preferred
Ability to adapt and adjust to a rapidly evolving environment
Ability to identify and plan critical path experiments in alignment with team objectives
Uses critical thinking to solve complex problems, address challenges and overcome obstacles
Understanding of appropriate statistical design and analysis for pre-clinical experiments
Highly effective interpersonal skills, ability to identify and absorbcritical information and convey it to relevant stakeholders
Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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