Scientist, in-vivo Pharmacology--non PhD
Pfizer Inc.
Washington – Bothell, NY
Job posting number: #7285312 (Ref:pf-4920430)
Posted: September 29, 2024
Job Description
This position is based at our Bothell, WA site which is approximately 15 miles from the downtown Seattle area.
We are seeking an experienced lab-based in vivo scientist with drug discovery experience to join our In Vivo Pharmacology Group. The qualified candidate is a highly motivated and interactive scientist who will participate in pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. The candidate will be dedicated to working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision-making. The individual will be capable of presenting scientific results to program key stakeholders.
ROLE RESPONSIBILITIES
Plan, execute and analyze in vivo pharmacology studies.
Utilizes a variety of tumor CDX/PDX/GEMM/Syngeneic models and drug administration routes to profile drug candidates and study MoA in tumor-bearing mice.
Conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Effectively manage study timeline and coordinate study logistics with cross functional program teams.
Quality documentation and interpretation of experimental results
Presentation of results within a multidisciplinary team environment.
Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards.
BASIC QUALIFICATIONS
BS in Biology or similar discipline with 6+years relevant in-vivo experience in an academic or industry environment OR
MS in Biology or similar discipline with 3+years relevant in-vivo experience in an academic or industry environment
Experience with animal models of human cancers.
Proficiency in cell culture, passaging and harvesting cells is required.
Hands on in vivo skills (IV, PO, SC, IP dosing), blood/tissue collection
Excellent written and oral communication and presentation skills
Experience integrating biological concepts into experimental design
PREFERRED QUALIFICATIONS
In vivo pharmacology experience in an Industry environment.
Highly skilled and proficient in the following in vivo Pharmacology techniques: tumor model development, subcutaneous tumor implantation, animal identification and randomization, tumor measurements by caliper.
Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation
Prior knowledge of downstream techniques example: PK bioanalytics, sample prep and processing for flow cytometry, histology and other PD assays
Highly motivated and ability to be flexible in case of changing priorities.
PHYSICAL/MENTAL REQUIREMENTS
· Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
· Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses)
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
· Must be willing and able to work after hours as needed to ensure study integrity
Work Location Assignment:On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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