Senior Scientist -- Downstream Process Development
Pfizer Inc.
Pearl River, NY
Job posting number: #7280535 (Ref:pf-4920058)
Posted: September 18, 2024
Job Description
Position Summary
You will contribute to downstream process development for various vaccine programs. You will work closely with the Principal Scientist/Senior Principal Scientist to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will regularly contribute at vaccine development meetings and represent the department on multidisciplinary teams. You will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.
Position Responsibilities
Lead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).
Develop continuous downstream process for drug substance.
Mentor junior scientists’ research activities and provide technical guidance when necessary.
Collaborate with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.
Lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.
Interact with Bioprocess Fermentation, Analytical, and Formulation Development groups to support downstream process development and in-process sample analysis activities.
Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer.
Prepare technical reports, critically review data, and evaluate new instrumentation and analytical techniques/approaches, as necessary.
Independently analyze and provide conclusions regarding experimental data generated.
Qualifications
Must Have
PhD degree in Biochemistry, Analytical Chemistry or related field,
Relevant downstream industry or postdoctoral research experience.
Extensive hands-on experience and strong background in chromatography and filtration.
Experience with bio-process downstream development.
Experience with nucleic acid or protein purification and characterization including FPLC, HPLC, UF/DF, UV/Vis, SDS-PAGE, and/or Fragment Analyzer/Tape station.
Experience mentoring junior level Scientists
Experience independently designing, planning, and executing purification / recovery activities.
Understanding of critical quality attributes of drug substance.
Proficient with a wide variety of software and information systems used in downstream process development platforms
Strong technical writing and presentation skills.
Nice To Have
Experience with tech transfer to manufacturing site
Experience with continuous processing
Physical/Mental Requirements
- Ability to perform complex data analysis.
Relocation support available
Work Location Assignment:On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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