Summary

A postdoctoral position is available immediately in the Fu laboratory in the Department of Medicine for a translational research project studying the role of circadian homeostasis in tumor suppression focusing on obesity-related hepatocellular carcinoma (HCC). The candidates are expected to have training background and techniques in molecular and cellular biology as well as mouse genetics and interpersonal skills in collaborating with clinicians and bioinformaticians. The project will use state-of-the-art technologies including RNA/ChIP-seq, in vivo nuclear run-on, proteomics, metabolomics, and humanized mouse models to define the role of circadian dysfunction in carcinogenesis and the pathophysiological mechanism and therapeutic targets specific to obesity-related non-alcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma (HCC).

Job Duties

• Workswith the PI for hypothesis development and experimental design.
• Performs bench work using various lab techniques and taking the major responsibility in conducting a research projects in studying the mechanism and therapeutic options of obesity-related HCC.
• Collaborates with clinicians, bioinformaticians, and lab member in lab research activities.
• Participatesin data processing, discussion, analysis, reporting, and manuscript preparation and conference presentations.
• Helpsthe PI and team in research and managing the lab.
• Mentorsjunior lab members.
• Applies tofellowships.
• Participates indepartmental and institutional research symposium and retreats.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• A recent Ph.D degree with less than two year experience in post-doctoral training.
• Prior first author publications in peer reviewed journals.
• Highly motivated to pursue an independent career in biomedical research.
• Excellent communication, time management and teamwork kills.
• Application documents needed: a cover letter to state research interests, an updated resume, and contact information of minimal three references.

Preferred training background:

• The candidates should have basic knowledge in molecular and cellular biology, liver biology and disease models, cancer, metabolism, obesity, and mouse genetics. The experimental expertise in studying mouse models, serum and liver biomarkers, gene expression, adenoviral techniques, primary hepatocytes, RNA and protein expression, and protein-protein (IP and co-IP) and protein-DNA interactions (CHIP) are preferred.