A Postdoctoral Associate position in the Department of Immunology is available under the mentorship of Dr. William Hawse at the University of Pittsburgh School of Medicine. The candidate will study research projects concerning signaling and T-cell differentiation.

T cells are mediators of the adaptive immune response. To properly mount a response, T cells use extracellular receptors to sense their environment and transduce signals to intracellular signaling networks. Following ligation of the T cell receptor (TCR) to an antigen, both phospholipid and kinase signaling networks are activated. Our lab's working hypothesis is that T cells encode different signaling inputs by generating different phosphatidylinositols and qualitatively different phosphoproteomes that drive alternate cellular differentiation programs. For this position, along with other lab members, our lab will utilize a combination of cellular immunology, mass spectrometry, biophysics, high-resolution microscopy, high-content imaging, chemical genetics, and single-cell assays to study the mechanisms underlying T-cell activation. 

Candidates will work directly with Dr. Hawse and will develop skills in a wide variety of computational and experimental techniques. The candidate will also develop several career-related skill sets, including manuscript preparation, oral presentations, and grant writing. 

The Candidate will be expected to work productively, diligently, conscientiously, and ethically on their research projects and any other assignments that Dr. Hawse, as the principal investigator, may request.  This Candidate's continued appointment is contingent on satisfactory annual progress and performance evaluations.

Salary is commensurate with experience and based on current 2023 NIH Stipend guidelines.

Qualifications:  Qualified Candidates will have earned a PhD Degree in Biology or a related field. 

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