Postdoctoral fellow: Genome engineering

The Wyss Institute for Biologically Inspired Engineering at Harvard University

Boston, MA

Job posting number: #7123691

Posted: February 8, 2023

Application Deadline: Open Until Filled

Job Description

About the Wyss:
The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances.

Role Description:
The laboratory of Dr. George Church at the Wyss Institute at Harvard Medical School in Boston, MA is looking for a Postdoctoral Fellow to join our rapidly growing team, interested in developing novel genome editing tools to overcome unmet needs in gene and cell therapies.

We are looking for a passionate, impact-motivated scientist and problem solver who relishes the opportunity to participate in fast-paced, dynamic research. Candidates should be focused on delivering impact through translational science, enjoy working with diverse groups of people, and leverage their expertise to create impactful innovations.

The Postdoctoral Fellow will have the opportunity to lead projects within the Wyss Institute’s HarborSite team focused on protein engineering and in vitro and in vivo characterization of genomic edits involving high-throughput, next-generation sequencing based techniques. Research will be performed in an interdisciplinary manner within the Wyss Institute and with collaborators in the Harvard Medical School community. We are particularly interested in scientists with strong wet lab experience in genome editing and protein engineering, ideally complemented with skills in computational genomics.

The postdoctoral fellow will also have opportunities relating to early-stage innovation and commercialization. The Church lab has a rich history of effectively translating novel technology concepts into new biotech startups. In addition to professional development opportunities within the lab and exposure to a breadth of scientific disciplines, the Postdoctoral Fellow will be able to take advantage of the scientific communities within Harvard, the Wyss Institute, and the greater Boston area.

What you’ll Need:
Ph.D. or equivalent
Specific degree areas include but are not limited to genome editing, protein engineering and design, mammalian synthetic biology, functional genomics, and/or nucleic acid delivery.
Background in biochemistry and biophysics of protein-DNA interactions is desired, but not required.
Knowledge of bioinformatic analysis of genomics datasets is desired, but not required.

Preferably, applicants should be able to:

Independently plan, design, and execute on mammalian genome editing experiments.
Design, clone, and test new enzyme variants for functional validation in vitro and in vivo.
Help manage and mentor our team of graduate students, research assistants, and undergraduate researchers
Initiate, maintain, and execute on both industry and academic collaborations relating to the application of our platform across diverse cell types and disease spaces
Accurately and thoroughly document experimental observations and protocols and help maintain a high level of organizational efficiency within the lab
Demonstrate a commitment to diversity, inclusion, and cultural awareness in the workplace through actions & communications with others
Prior experience with primary human cell isolation, culture, and modification is necessary.
Prior experience with molecular cloning methods, flow cytometry and next-generation sequencing is necessary.
Familiarity with python, R or similar programming language for genomic and transcriptomic analyses are desired, but not required
Highly effective organizational and communication skills are essential

Where You Can Apply:
Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications should be sent to [email protected] using the subject line “HarborSite Postdoc application.”

Working Conditions:
Harvard requires COVID vaccination for all Harvard community members. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage:

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

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More Info

Job posting number:#7123691
Application Deadline:Open Until Filled
Employer Location:The Wyss Institute for Biologically Inspired Engineering at Harvard University
United States
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