Associate Director, Biochemical (Gene Therapy Program)

University of Pennsylvania

Philadelphia, PA

Job posting number: #7108505

Posted: August 19, 2022

Application Deadline: Open Until Filled

Job Description

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America’s Best Employers By State in 2021.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

COVID-19 vaccination is a requirement for all positions at the University of Pennsylvania. New hires are expected to be fully vaccinated before beginning work at the University. For more information about Penn’s vaccine requirements and the use of Penn Open Pass, visit the Penn COVID-19 Response website for the latest information.

Posted Job Title

Associate Director, Biochemical (Gene Therapy Program)
Job Profile Title

Associate Director E
Job Description Summary

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Continuation of all GTP positions is contingent upon funding.
Job Description

Our Vector Operations group, comprised of Manufacturing Sciences and Technology (MS&T), Analytical Sciences and Technology (AS&T) and External Manufacturing (EM) teams, provides manufacturing and analytical support of basic, translational and clinical research. The MS&T team is composed of teams that conduct platform development, process development and optimization, vector manufacturing and process technical transfer. The AS&T team conducts analytical development, quality control and assay technical transfer. The AS&T organization includes a molecular team, biochemical team, bioassay team and physical/chemical team.

Due to significant growth, the Vector Core is looking for a new Associate Director to support technical and managerial oversight and participation in assay development and/or product characterization and release to support research, IND-enabling studies and clinical trials.

As an Associate Director, you are expected to bring subject matter expertise into one or more of the analytical areas within the analytics organization as well as potentially emerge as a subject matter expert in either molecular, biochemical, cell-based or physical/chemical assays. You will be providing technical direction and/or managerial oversight as well as participate in the development and/or conduct of quality control assays to determine the identity, quality, quantity, purity, potency and/or physical characteristics of viral-based vectors. You will provide direction in the implementation of new technologies and development of new methods as well as oversee or conduct analytical testing using established protocols or standard operating procedures (may be conducted under GxP conditions). You will be documenting your activities in development reports and/or test records or in a database and may be participating in the establishment of new information management systems. You will be providing training for junior level staff on analytical testing methods and procedures. You will also working in collaboration with analytical leadership, to author, review, and/or revise protocols and standard operating procedures as needed.

You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have expertise with one or more of the following: mammalian cell culture, aseptic technique, molecular, biochemical, cell-based and/or physical/chemical assays. The techniques that are used across the vector analytics teams include qPCR, ddPCR, SDS-PAGE, ceSDS, Enzymatic Assays, ELISA, MSD, In-Cell Western, High Content Imaging, Analytical Ultracentrifugation, Size Exclusion Chromatography, Dynamic or Multi-Angle Light Scattering and Mass Spectrometry.

Qualifications:

BS degree in Chemistry, Biology, Chemical Engineering or related disciplines with 5-7 years of experience required

Must have experience with one or more of the following: molecular, biochemical, cell-based or physical/chemical techniques

Must be meticulous, detail oriented, and analytical

Must be highly motivated, have excellent organizational, communication and interpersonal skills.

Must be able to work independently and as part of a multi-disciplinary team



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