Senior Scientist, RNA Biotherapeutics Discovery Analytics

Pfizer Inc.

Cambridge, MA

Job posting number: #7106315 (Ref:4839179)

Posted: July 25, 2022

Application Deadline: Open Until Filled

Job Description

Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve
We are seeking a highly motivated Senior Scientist to join the Molecular Assessment and Profiling group in BioMedicine Design as part of large molecule therapeutic discovery effort. The candidate will work with an innovative team of scientists to develop RNA-based therapeutics to bring curative treatments to patients. This individual will plan, execute and provide in-depth biochemical and biophysical characterization of RNA-based therapeutics in discovery research and development. In addition, this person will contribute to the development of innovative assays/methods for RNA/LNP physicochemical characterization. Successful candidate will work in a fast-paced environment managing multiple projects and contribute to team’s deliverables.
How You Will Achieve It
Perform comprehensive molecular characterization, biophysical analysis, and stability assessment of RNA-based therapeutics
Critically analyze and present experiment results across multiple teams spanning general to subject expert audiences
Provide scientific guidance and decision to move project along discovery pipeline
Drive technology innovation; evaluate new technologies and instrumentations
Work closely with cross-functional teams including therapeutic discovery teams, production groups, MS and development organization to plan and execute deliverables
MS with 5+ years or PhD with 0-3 years of relevant experience in Molecular Biology, Biochemistry, Biophysics or related discipline
Knowledgeable with a wide range RNA and lipids nanoparticle characterization techniques including RNA integrity (5’ capping, 3’ polyA and CGE), chromatography techniques (SEC, RP-HPLC/UPLC), LNP lipid characterization, RNA packaging efficiency, zeta-potential charge and DLS size/PDI analysis
Hands on molecular biology experience with qPCR/ddPCR (including primer/probe design), method validation, assay development, and troubleshooting
Ability to manage multiple projects with overlapping timelines.
Highly organized, excellent communication, presentation and documentation skills
Experience in therapeutic drug discovery and biochemistry research
Working experience with RNA and LNP analytics is highly desirable
Demonstrated track record of independent research and scientific publications in peer reviewed journals
Other Job Details

Relocation support available
Eligible for Employee Referral Bonus

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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