Postdoctoral Fellow - RNA Splicing Dysregulation, DNA Damage Response, and Oncogenesis in Blood Malignancies

City of Hope

Monrovia, CA

Job posting number: #7085072 (Ref:10009480-4)

Posted: September 10, 2021

Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Wang Laboratory at the Department of Systems Biology, Beckman Research Institute, City of Hope, is seeking for a talented and motivated Postdoctoral Fellow to lead the project for RNA splicing dysregulation, DNA damage response, and oncogenesis in blood malignancies. Candidates with strong background in RNA splicing, DNA damage, cancer biology, animal models, and bioinformatics are encouraged to apply. Wang Laboratory is currently funded by two R01 grants, foundation grants, and City of Hope Startup package.

Lab Publications:

Yin SY, Gambe R, Brooks AN, Sun J, Fan J, Seiler M, Obeng E, Zhang W, Wan Y, Cibulskis CL, Neuberg D, Buonamici S, Smith PG, Campagna D, Meyerson MM, Fleming MD, Ebert BJ, Carrasco RD, Wu CJ, Wang L. A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion. Cancer Cell. 2019, 35: 283-296

Wang L , Brooks AL, Fan J, Wan Y, Gambe R, Li S, Hergert S, Freeman SS, Levin JZ, Fan L, Seiler M, Buonamici S, Smith PG, Chau KF, Cibulskis CL, Zhang W, Rassent LZ, Ghia EM, Kipps TJ, Fernandes S, Bloch DB, Kotliar D, Landau DA, Shukla S, Aster JC, Reed R, DeLuca DS, Brown JR, Neuberg D, Getz G, Livak KJ, Meyerson MM, Kharchenko PV, Wu CJ. Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia. Cancer Cell. 2016 30(5): 750-763. PMC5127278

Wang L , Fan J, Francis J, Zhang C, Herger S, Gambe R, Li S, Zhou C, Yang C, Xiao S, Dal Cin P, Bowden M, Kotliar D, Shukla S, Brown JR, Neuberg D, Livak KJ, Kharchenko PV, Wu CJ. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res 2017 27 1-13

Basic education, experience and skills required for consideration:
  • An M.D. or Ph.D. degree in hematology, molecular biology, cancer biology, or a related discipline is required
  • Understanding fundamental mechanism of DNA damage is required
  • Knowledge in transcriptome analysis is preferred
  • Familiar with genetic murine models is preferred
  • Excellent verbal and written communication skills
  • Self-motivated, independent and creative


Additional Information:
  • For consideration, please directly send a CV, a brief statement of scientific research interests, contact information for at least two references and start date availability to: lilwang@coh.org .
  • For detail laboratory information, please visit: https://www.cityofhope.org/research/systems- biology/systems-biology-research-labs/lili-wang-lab . Twitter: https://twitter.com/LiliWangLab


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

#PD

  • Posting Date: Jan 13, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job


City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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