Research Technician III - Human Genome Sequencing Center - Clia Lab

Baylor College of Medicine

Houston, TX

Job posting number: #7084726 (Ref:8524-en_US)

Posted: September 3, 2021

Application Deadline: Open Until Filled

Job Description


The BCM-HGSC was founded in 1996 under the leadership of Dr. Richard Gibbs and is a world leader in genomics. The fundamental interests of the BCM-HGSC are in advancing biology and genetics by improved genome technologies. As one of the large-scale sequencing centers funded by the National Institutes of Health, the BCM-HGSC provides a unique opportunity to work on the cutting edge of genomic science in a state of the art institution.


The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine is seeking to recruit a Research Technician III to work in its CLIA laboratory conducting next-generation sequencing assays.


Qualified candidates should have molecular biology experience and good organizational skills. The position would involve one or more of the following duties: DNA and RNA QC, Real-time PCR, and library construction. Proficiency in MS Word and MS Excel is necessary. Qualified candidates should be good at multi-tasking, problem-solving, and have strong communication skills. The candidate should be able to work well in a team environment.
A Bachelor's degree in a basic science or equivalent is required. Previous related experience is preferred but not required.


The candidate should be able to work independently and within the CLIA team. They should be flexible and adapt to the pipeline requirements and complete assigned tasks in a timely manner. Qualified candidates should be good at multi-tasking, problem-solving, and have strong communication skills.

Job Duties

• Perform pipeline production in CL for NGS library preparation with liquid handling systems
• Conduct laboratory routine instrument maintenance, reagent testing and consumable tracking to keep production going without interruption
• Participate in lab compliance activities to comply CAP, CLIA, HIPPA and all relevant Federal, State and local regulations
• Initiate Automation library report for QC metrics and reagent lot records.
• Array and prepare samples for Covaris application and QC documentation.
• Prepare Illumina paired end library on Biomek FXP, which also includes Agilent QC, Alphaview QC, pooling and Ampure bead cleanup.
• Preparation of Illumina Adaptor Trays, Binding buffer, and aliquoting reagents necessary for library prep.
• Provide detailed and legible library documentation associated with results, maintenance records, and quality control.
• Ordering reagents and labware needed for automated preparation of Library.
• Performing monthly inventory of automation pipeline reagents
• Routine maintenance of automated equipment.
• Assist and train staff in basic molecular biology processes for library preparation.
• Assist team lead in updating management with HGSC-CLIA robotic updates.
• Participate in library troubleshooting as assigned.
• Validate Robotic scripts for library preparation & report results to management.
• Assist Robotics Team in Biomek script development. Work with Robotics Team to implement Biomek Methods for automated library preparation.
• Staying current with Next Generation Sequencing Literature.

Minimum Qualifications

  • Bachelor's degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
  • One year of relevant experience.

Preferred Qualifications

  • Master's degree in a related field.





Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.



Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.

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