Postdoctoral Fellow (Platelets - Vacant Position for Vahid Afshar-Kharghan's Laboratory)

The University of Texas M. D. Anderson Cancer Center

Houston, TX

Job posting number: #7081082

Posted: July 13, 2021

Application Deadline: Open Until Filled

Job Description

Position/Program Description:
This position will study the role of the platelets in the progression of cancer and on the mechanisms of platelet extravasation into tumors.
1. To design and conducts in vitro experiments on the role of platelets in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of platelets on immune cells (neutrophils, T cells, B cells, and antigen-presenting cells)
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of platelets on the growth and metastasis of different cancers, and the therapeutic benefit of platelet inhibitors on blocking tumor growth.
4. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelet extravasation into the tumor microenvironment.
5. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelets on the immune profile of tumor microenvironment.
6. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
7. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
8. To conduct DNA, RNA, and protein extraction and purification.
9. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
10. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
11. To communicate freely and clearly, but also to be respectful to other lab members.
12. Records the experiments and results meticulously.
13. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.

Learning Objectives:
- Learning to design and conduct experiments in vitro and in mouse models of cancer
- Learning to troubleshoot and analyze the generated data
- Learning important topic in platelet biology, imaging studies, immune profiling tumor microenvironment, mouse genetics

Eligibility Requirements:
-Ph.D. in biological sciences
-Familiarity with murine studies
-Familiarity with basic laboratory techniques, such as ELISA, Western-blotting, flowcytomtery, RT-PCR, PCR, RNA, and DNA extraction
-Familiarity with imaging studies including immunohistochemistry and immune fluorescence microscopy


It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html


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