Staff Scientist - Cell Signaling and Transcription Regulation in Development and Oncogenesis

City of Hope

Duarte, CA

Job posting number: #7079630 (Ref:10011356)

Posted: July 26, 2022

Application Deadline: Open Until Filled

Job Description

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution.  AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities.  Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding.  We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

A Staff Scientist position is available in a highly competitive research lab at City of Hope, one of a prestigious group of NCI-designated Comprehensive Cancer Centers. 

The successful applicant will join a highly competitive and productive research lab immediately to investigate molecular mechanisms underlying transcriptional control and cell signaling during cancer initiation and progression. The applicant will use “cutting-edge” and innovative genetically engineered mouse models and other advanced and unbiased biological approaches to uncover gene-expression and genomic and epigenetic alterations that regulate oncogenic transformation and related cellular events in tumorigenesis.

This Staff Scientist position is designed for very capable research professionals who have previous research experience, skills, and analytic ability to lead sophisticated research projects that are focused on the field of cancer biology and stem cell biology.  The candidate should also have a proven track record of creativity and productivity, as well as previous experience in designing and performing daily experiments with GEM models.  The candidate should be able to help the PI in drafting research proposals and manuscripts and evaluates research data and develops new experimental approaches.  He/she should be able to work under stress in order to meet deadlines. He/she should also be able to assist the PI to train lab staff in specialized procedures, equipment and theoretical concepts behind unique tests. We provide a fruitful research and training environment and competitive salary and fringe benefit.

Basic education, experience and skills required for consideration:

  • Ph.D. or M.D/Ph.D. degree in Cancer Biology, Molecular Biology, Genetics, Biochemistry, Cell Biology, or a related field.
  • Previous experience with mouse models of human diseases, cancer biology, molecular biology, or genetics is highly desired.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

  • For more information about Dr. Zijie Sun’s lab, please visit here.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.    


City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.

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