Postdoctoral Fellow - Cutaneous T cell Lymphoma - Christiane Querfeld Lab

City of Hope

Duarte, CA

Job posting number: #7073683 (Ref:10007290)

Posted: November 23, 2022

Application Deadline: Open Until Filled

Job Description

Post-doctoral Fellow position is available immediately in the laboratory of Dr. Christiane Querfeld, M.D., Ph.D. at Beckman Research Institute of City of Hope.

 

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution.  AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities.  Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding.  We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

About the Querfeld Laboratory

Christiane Querfeld, M.D., Ph.D., director of the Cutaneous Lymphoma Program, seeks better treatment options for cutaneous T cell lymphoma (CTCL), a rare form of lymphoma that first appears on the skin but can also spread to lymph nodes and internal organs. City of Hope is one of the few institutions in the country that offers clinical trials to treat cutaneous lymphomas. Dr. Querfeld leads a multidisciplinary team of experts, including medical and radiation oncologists, pioneering treatments for CTCL and its subtypes.

Dr. Querfeld’s laboratory investigations are focused on the microenvironment in CTCL funded by NIH-NCI R01 and LLS scholar grants. She has demonstrated that cancer growth is fostered by the surrounding nonmalignant cells. These observations have led to the initiation of several targeted and immunologic therapies to restore the immune system and hereby killing the cancerous cells. Examples include a microRNA (miR155) antagomir that inhibits proliferation, an anti-CD47 construct enhancing macrophage killing and a randomized investigator initiated trial comparing the checkpoint inhibitor anti-PD-L1 with/without the immunomodulatory drug lenalidomide. Her fundamental laboratory research activities involve dissecting key signaling pathways to advance therapeutic immunologic strategies including mechanisms of resistance.

Key Responsibilities include:

  • The ideal candidate should fit well with our research team focusing on the tumor microenvironment in cutaneous T cell lymphoma.
  • Our research aims to identify the underlying mechanisms that promotes CTCL growth; specifically, the impact of immune cells such as macrophages and Tregs and to define novel targets.
  • Expertise in handling of high-dimensional analysis of primary tissues, including multi parameter flow cytometry, immunohistochemistry, multiplex imaging and/or gene expression profiling, microRNA analysis, exosomes isolation and analysis (EG) for microRNA proteins cancer detection therapy is highly preferred.
  • Participate in the preparation of research grants, manuscripts and presentations.
  • Ensures that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.
  • The candidate must follow established City of Hope and department policies, procedures, objectives, performance improvement, attendance, safety, environmental, and infection control guidelines, including adherence to the workplace Code of Conduct and Compliance Plan. Practices a high level of integrity and honesty in maintaining confidentiality.
  • Performs other related duties as assigned or requested.

Minimum Education and Skills Required for Consideration

1. A Ph.D. degree in life or biomedical sciences, or a related discipline is required.

 2. Ability to effectively work and collaborate in a translational research environment in order to successfully meet deadlines and perform and prioritize simultaneous tasks. Requires use of discretion and judgment when handling confidential information.

 3. Ability to design and execute experiments, critically interpret experimental results, and present data in a cogent and meaningful manner.

 4. Candidate be industrious, has sound technical skills and capable drafting grant proposals, research protocols and manuscripts.

 5. Under minimal direction of the Principal Investigator, works and is responsible for the development and execution of major research project and performs state-of-the-art, complex research projects in collaboration with the other researchers, making significant, original contributions to research methods; including authorship or co-authorship of published findings.

 6. Ensures that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.

Additional Information:

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer.  All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.



City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.


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