Postdoctoral Fellowhips

Brigham and Women's Hospital

Boston, MA

Job posting number: #7056198

Posted: February 27, 2019

Application Deadline: Open Until Filled

Job Description

A postdoctoral position is available for a highly motivated Ph.D., or M.D. Ph.D., who will dedicate his/her postdoctoral study to the fields of “skeletal and cardiac muscle hypertrophy”, “regeneration”, “RNA biology”, and “gene therapy”. The projects are focused on understanding how non-coding RNAs modulate the cellular and molecular mechanisms underlying muscle homeostasis and the progression of disease. Prior experience in small animal surgeries is a plus.

The fellow will drive a new project focusing on uncovering the molecular mechanisms regulating the progressive loss of functional performance, in both skeletal and cardiac striated muscles, as a function of age. This project seeks to uncover the molecular mechanism and biological role of two novel long non-coding RNAs (lncRNAs) in modulating myocytes adaptations to physiological stress. This project will make use of novel mouse genetic models, Chromatin Immunoprecipitation (ChIP), next generation RNA sequencing, and more traditional cellular and molecular biological techniques. It is anticipated that new findings will help uncover the mechanisms underlying muscle atrophy and the progression of myocardial remodeling with advancing age. Thus, the successful accomplishment of the project will allow the fellow to launch a promising research career in skeletal and/or cardiac muscle biology. For more information on research projects available in the lab, please see https://www.nepplresearchgroup.org/

Candidates must have a recent Ph.D., M.D., or M.D./Ph.D. in biological sciences and a strong publication record. They should demonstrate proficiency in written and spoken English and in communicating scientific research findings accurately. Strong writing skills are essential, as well as a track record of first authorship for peer reviewed publications. The candidate must be able to conduct independent research while collaborating with others in a large interdisciplinary open laboratory setting.

The ideal candidate will have expertise in at least two of the following areas: stem cell biology, skeletal muscle or cardiac muscle biology, Chromatin Immunoprecipitation, epigenetic regulation, RNA biology, molecular biology, and cell signaling. Experience with the mouse model organisms is required.

The position provides an exciting opportunity to work at the interface of basic and translational research in the collaborative and stimulating environment of Brigham and Women’s Hospital, Harvard Medical School, and the Longwood Medical Area. Brigham and Women’s Hospital is a teaching affiliate of Harvard Medical School, and provides multiple career development programs for trainees and a highly interactive multidisciplinary research environment.

Interested candidates should send a CV, a description of research interests and career goals, and contact information for three references to:
Dr. Ronald Neppl
Department of Orthopedic Surgery
Brigham and Women’s Hospital
Harvard Medical School
75 Francis Street
Boston MA 02115
Email: rneppl@bwh.harvard.edu



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