Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist at the Early Clinical Development Group, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be a member of our growing ligand binding assays and proteomics team and contribute to large scale proteomics efforts. You will contribute to the development and validation of clinical biomarker assays, execution of high-throughput biomarker analysis, strategies for biomarker testing, and results communication, reporting and QC. Communicating with Pfizer key stakeholders and different research units will also be part of your role.

You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team.  Your creativity in developing novel processes and new ideas for biomarker studies will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Assist Clinical Biomarker Leads to develop, optimize, validate, and perform ligand binding assays and large-scale biomarker assays to support biomarker discovery, proof of mechanism and PD biomarker studies.
• Conduct MSD, ELISA, large-scale proteomics and other relevant multiplex assays on clinical samples in accordance with Good Clinical Laboratory Practices (GCLP) requirements.
• Identify, trouble-shoot, and optimize relevant assay systems, technologies, and readouts.
• Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings.
• Maintain regulatory compliance appropriate for clinical and preclinical study execution including all proscribed training as found in ECD SOPs and training transcripts. This includes knowledge, training and understanding of GLP/GCP guidance for execution of preclinical and clinical studies supporting Pfizer portfolio projects as applicable.
• Responsible for QC and peer review of raw data, results, and final reports from other colleagues within the regulated group (depending on level of training).
• Proactively gathers input from colleagues, teams & management to avoid/address issues at functional level and participates on cross discipline matrix teams.
• Excellent oral/written communication and organizational skills. Demonstrated ability to communicate bioanalytical information (including Q&A)
• Understanding of “fit-for-purpose” assay development and support.  Ability to effectively balance assay rigor against resource needs and study goals.

Qualifications

Must-Have

• Masters' degree or PhD in biology, chemistry or equivalent and 5+ years of relevant experience in industry or GLP environments.
• Expertise and hands-on experience with ELISA, MSD, Western Blot, and multiplex platforms.
• Experience in automation and high throughput proteomic analysis is preferrable.
• Technical knowledge of assay validation for clinical applications
• Ability to perform complex data analysis and work in multidisciplinary teams.
• Proven track record of scientific presentations and peer-reviewed publications

Nice-to-Have

• Extensive experience in immunology, disease research, or related fields, and a desire to continue in a laboratory-focused role
• Proficiency with personal computers including word processing, spreadsheets, Excel, PowerPoint and relevant scientific software is desirable
• Specific expertise in the study of cytokines and chemokines in cancer and inflammatory processes.

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, ability to perform mathematical calculations and ability to perform complex data analysis.

Relocation assistance may be available based on business needs and/or eligibility.