Job Description

ROLE SUMMARY
We are seeking an experienced Process Chemist to join our Chemical Research and Development (CRD) Team in Groton, CT. CRD, as part of Worldwide R&D and Medical in Pharmaceutical Sciences, is responsible for the development of process technology for the production of active pharmaceutical ingredients (API). This role is part of the late-stage Process Chemistry group in Groton (Process Chemistry Development and Optimization-PCDO) and pertains to completion of chemistry development activities to support clinical milestones and successful technology transfer to our manufacturing partners Pfizer Global Supply (PGS).

The role requires both direct lab work as well as technical oversight and supervision of 2-3 process chemists. Training members of the new lab around Science of Scale is an essential responsibility, in particular around developing scalable processes which are safe, efficient and robust, use of the state-of-the-art equipment, and the use of computational and predictive tools. Excellent communication skills are required to ensure connectivity with both the broader CRD group, as well as an ability to represent process chemistry on multi-disciplinary teams.

The successful candidate will develop and optimize scalable processes for the production of active pharmaceutical ingredients (API) for late-phase development programs, applying innovative chemistries, new technologies and statistical experimental design approaches. The ability to work on and collaborate with multi-disciplinary teams involving chemists, analysts, engineers, and technologists, and to represent CRD on cross-functional teams is essential. Partnership with manufacturing specialists for API synthesis in the Kilo Lab (Groton, CT), Process Development Facility (Sandwich, UK), and PGS (Ringaskiddy, IR) is critical, as well as preparing documentation and knowledge to support technology transfer.

ROLE RESPONSIBILITIES
Individual lab work focused on later-phase development workflows and ensuring project readiness with a focus on documentation and achieving program milestones. The use of the state-of-the art equipment, analytical technology, computational and predictive tools highly desired.

Supervision, including oversight and training, of 2-3 colleagues initially and potentially additional scientific staff in the future.

Strong oral communication skills including face to face and remote interactions with supervisor and other CRD colleagues in Groton/Sandwich/Ringaskiddy, as well as interactions with other Groton colleagues, in particular Analytical Chemistry, Quality, and Chemistry Manufacturing and Control (CMC).

Excellent written communication skills, including the ability to maintain an accurate scientific notebook, draft concise written reports, publications, and the authoring of regulatory documents.

Representing process chemistry on API project teams in the post-POC arena with the ability to work in multi-disciplinary teams involving analysts, process safety scientists, engineers, and technologists as an essential skill.

Partnering with remote manufacturing specialists for API synthesis in the Kilo Lab/PDF/PGS, as well as providing support for technology transfer to CMOs, including the preparation of technical transfer documents through validation and launch readiness.

Compliance on safety and regulatory requirements.

Travel is occasionally required in support of manufacture (Groton, Sandwich, Ringaskiddy) and to engage with the broader CRD team, and to participate in scientific conferences.

Participation in key initiatives for CRD and contributing to continuous improvement work in the department and advancement of the Process Chemistry discipline through technology, workflow or business impact.

BASIC QUALIFICATIONS
Bachelor’s Degree in chemistry and 12+ years’ experience in Chemical Research and Development OR MS degree in Organic Chemistry with 9+ years’ experience in Chemical Research and Development OR PhD in Organic Chemistry and 2+ years’ experience in Chemical Research and Development.
PREFERRED QUALIFICATIONS
PhD. in Organic Chemistry, with 4-7 years of pharmaceutical R&D experience in Process Chemistry.
State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis and physical organic chemistry as it relates to reaction mechanism is expected. The ability to employ analytical tools and automated laboratory technologies to enhance process development efficiency is desirable. Excellent written and oral communication skills, the ability to effectively influence the work of others, and a general knowledge of drug development and the pharmaceutical industry are key.


PHYSICAL/MENTAL REQUIREMENTS

Laboratory work requiring standing and working at a computer.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Travel may be required on occasion to Sandwich, UK or Ringaskiddy, IR in support of internal technology transfer to API manufacturing facilities or internal face-to-face meetings, or to participate in scientific conferences.


Additional Information:

Relocation support available
Eligible for Employee Referral
Work Location Assignment: On Premise