Senior Staff Scientist: Organ Chip-Enabled Drug Development
Job posting number: #7075744
Posted: March 5, 2021
Application Deadline: Open Until Filled
Job DescriptionJob Summary :
The Wyss Institute for Biologically Inspired Engineering at Harvard University is not a typical research organization. Our mission is to transform healthcare and the environment by emulating the way nature builds, and getting our innovations out of the lab and into the real world, fast. At the Wyss Institute, faculty from premier academic and clinical institutions collaborate with staff scientists, postdocs, graduate students, industry experts, business development leaders, and entrepreneurs across disciplines to produce new technologies that don’t just succeed at making it to the market – they disrupt it. We support research that universities, companies, and VC firms don’t fund because they claim it’s too risky. We prefer to use the word “challenging,” and we love challenges. For more information, visit: http://wyss.harvard.edu/
You are a collaborative, impact-focused problem solver who wants to lead a dynamic team dedicated to creating and commercializing novel therapeutic capabilities. You want the freedom to explore, to push the boundaries of what is possible, and to use your ambition to tackle challenging projects in a fast-paced, industry-focused environment without a lot of administrative hurdles. You enjoy working with diverse groups of people and leveraging your expertise to create innovations that can change the world.
About the Role:
We are looking for an innovative Scientist or Engineer with significant expertise in drug development and bioengineering to join our Bioinspired Therapeutics and Diagnostics team. Reporting to the Technology Translation Director and working closely with Founding Director and Core Faculty Member, Dr. Donald Ingber, you will perform highly interdisciplinary research that leverages microengineered Organ Chip technology and other in vitro culture models to discover new disease mechanisms, identify therapeutic targets, and develop novel drugs and biologic compounds. This role also involves managing a group of scientists and engineers of all levels (staff, post-doc, and technicians) and coordinating their efforts to achieve deliverables for sponsored research programs, as well as helping to drive future advances in Organ Chip technology and drug discovery. To learn more about our Organ Chip bioinspired technologies, go to: https://wyss.harvard.edu/technology/human-organs-on-chips/
What you'll do:
- Direct sponsored research programs that design and develop therapeutics by leveraging microfluidic human Organ Chip in vitro experimentation technology
- Lead, manage, and mentor junior team members with regards to their professional development as well as executing grant deliverables in a timely manner; Direct complex work flows on initiatives.
- Supervise the implementation and execution of experiments at the bench using in vitro cell based assays, primary cell culture, iPS cells, organoids, cell based-microfluidic Organ chip assays, and molecular, biochemical and genetic analysis methods; advise, assist, and mentor with regards to engineering challenges.
- Collaborate with bioinformaticians, engineers, chemists, and computational scientists across the Institute to meet program goals.
- Collaborate with other project platform and business development teams to help identify and establish commercial opportunities, licensing structures and start up strategies within our therapeutics and diagnostics programs. Work with collaborating labs and CROs to generate multi-omic data from human Organ Chip experiments
- Oversee and assist in the design and implementation of experimental protocols and procedures
Write reports and presentations; assist in the preparation and publications, patents, and grant applications, providing critical data, figures, and other technical information
- Act as a major point of contact with grant sponsors
- Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others
What you'll need:
-Master’s degree in Bioengineering, Biotechnology, Cell Biology, Physiology, Cancer Biology, Pharmacology or related field required.
- 9 or more years of experience working in bioengineering, cell biology, physiology or related field. A PhD may count towards years of experience.
- PhD in Bioengineering, Biotechnology, Cell Biology, Physiology, Cancer Biology, Pharmacology or related field strongly preferred
- 4 or more years of experience working in academia and/or industry in drug development and cell, tissue, or organ assays is strong preferred.
- Experience with any of the following disease areas: cancer, lung disease, infectious diseases gastrointestinal, and female reproductive disorders would be helpful
- Experience with drug development, cancer, stromal-epithelial interactions, blood brain barrier, microvascular cells as well as IPS-derived cells and organoid-based cultures would be helpful
- Strong organizational and communication skills to assist and collaborate with a multidisciplinary group of technology innovators, engineers, biologist and clinicians
- Demonstrated ability to tackle and lead multiple projects while simultaneously performing bench work as a member of an integrated team is essential